October 2015

Bayer develops the first two-way insecticide mixture for indoor residual spraying against malaria vectors

Consistent with our mission of delivering ‘Science For A Better Life’, we have recently submitted a dossier to the World Health Organization Pesticide Evaluation Scheme (WHOPES) for the evaluation of a new two-way insecticide mixture which includes a new mode-of-action for indoor residual spraying (IRS) against disease vectors. Named Fludora™ Fusion, this first two-way IRS mixture (based on two active ingredients) is intended to provide an effective solution to help African disease control programs address the challenge of insecticide resistance in malaria-transmitting mosquitoes. Trials with the product have shown excellent results against many different kinds of insecticide resistant mosquito strains and strong performance across a wide range of surfaces. Bayer foresees the WHOPES evaluation and testing process to take about 2 years and anticipates market availability of the product before the end of 2017.

“We have been able to draw upon experience from other pest control situations, including agriculture, where mixtures have been shown to be very effective in situations where insecticide resistance is present”, said Frederic Schmitt, (Global Project Manager Vector Control). "In Fludora Fusion we have taken the decision to pair up a new insecticide with an unrelated mode of action as a two-way mixture”.

Malaria is one of the leading causes of infant mortality in Sub-Saharan Africa and a significant barrier to economic development. Vector control of malaria-transmitting mosquitoes remains critical to the success of its elimination. However, insecticide resistance in mosquitoes against the currently used insecticides threatens the significant gains made in the fight against the disease in the last 15 years. Commonly, resistance is managed by rotation of alternative modes of action, but unfortunately there are currently only four insecticide classes available for malaria vector control, which limits potential management strategies.

“Given the current situation with insecticide resistance, any new insecticide is precious and must be introduced in a way which gives it the best possible chance of remaining useful for malaria control programs for the long-term”, added Justin McBeath, Market Segment Manager Malaria Vector Control. "Used in conjunction with an integrated vector management approach, we think this innovation could continue to be a valuable tool long into the future".

Active in the field of vector control for more than 50 years, we remain committed to supporting the fight against malaria through the development of new tools which address challenges such as insecticide resistance. We are convinced that Fludora Fusion will have a good fit into vector-borne disease control programs and deliver the best outcomes in helping to protect and improve the lives of those at risk from malaria.